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MwPharm references


MwPharm won critical acclaim in 2013 and was awarded the world's best TDM software:

Fuchs A, Csajka C, Thoma Y, Buclin T, Widmer N.: Benchmarking therapeutic drug monitoring software: a review of available computer tools. Clin Pharmacokinet. 2013 Jan;52(1):9-22. doi: 10.1007/s40262-012-0020-y.


Proost JH, Meijer DK.: MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Comput Biol Med. 1992 May;22(3):155-63.


Neef C, Jelliffe RW, van Laar T, Loohuis T, Essink AW, Janssen EN.: Comparison of two software programs to be used for the calculation of population pharmacokinetic parameters. Int J Biomed Comput. 1994 Jun;36(1-2):143-50.




Mouton JW, Vinks AA, Punt NC.: Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion. Antimicrob Agents Chemother. 1997 Apr;41(4):733-8.


Op den Buijsch RA, van de Plas A, Stolk LM, Christiaans MH, van Hooff JP, Undre NA, van Dieijen-Visser MP, Bekers O.: Evaluation of limited sampling strategies for tacrolimus. Eur J Clin Pharmacol. 2007 Nov;63(11):1039-44. Epub 2007 Aug 22.


Alffenaar JW, Kosterink JG, van Altena R, van der Werf TS, Uges DR, Proost JH.: Limited sampling strategies for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis. Ther Drug Monit. 2010 Feb;32(1):97-101. doi: 10.1097/FTD.0b013e3181cc6d6f.


Kerkhofs T, Derijks L, Ettaieb M, den Hartigh J, Neef C, Gelderblom H, Guchelaar HJ, Haak H.: Development of a Pharmacokinetic Model of Mitotane: Towards Personalized Dosing in Adrenocortical Carcinoma. Ther Drug Monit. 2014 May 30.


Ter Laak MA, Roos C, Touw DJ, van Hattum PR, Kwee A, Lotgering FK, Mol BW, van Pampus MG, Porath MM, Spaanderman ME, van der Post JA, Papatsonis DN, van 't Veer NE.: Pharmacokinetics of nifedipine slow-release during sustained tocolysis. Int J Clin Pharmacol Ther. 2014 Nov 19.


Boereboom FT, van Dijk A, van Zoonen P, Meulenbelt J.: Nonaccidental endosulfan intoxication: a case report with toxicokinetic calculations and tissue concentrations. J Toxicol Clin Toxicol. 1998;36(4):345-52.


Pullen J, de Rozario L, Stolk LM, Degraeuwe PL, van Tiel FH, Zimmermann LJ.: Population pharmacokinetics and dosing of flucloxacillin in preterm and term neonates. Ther Drug Monit. 2006 Jun;28(3):351-8.


Cremers SC, Scholten EM, Schoemaker RC, Lentjes EG, Vermeij P, Paul LC, den Hartigh J, de Fijter JW.: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas-kidney transplant recipients. Nephrol Dial Transplant. 2003 Jun;18(6):1201-8.


Valik D, Sterba J, Bajciova V, Demlova R.: Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. Oncology. 2005;69(3):269-72. Epub 2005 Sep 15.


Worrall SP, Almond MK, Dhillon S.: Pharmacokinetics of bupropion and its metabolites in haemodialysis patients who smoke. A single dose study. Nephron Clin Pract. 2004;97(3):c83-9.


Schreuder MF, Wilhelm AJ, Bökenkamp A, Timmermans SM, Delemarre-van de Waal HA, van Wijk JA.: Impact of gestational age and birth weight on amikacin clearance on day 1 of life. Clin J Am Soc Nephrol. 2009 Nov;4(11):1774-8. doi: 10.2215/CJN.02230409. Epub 2009 Aug 27.


Alffenaar JW, Nienhuis WA, de Velde F, Zuur AT, Wessels AM, Almeida D, Grosset J, Adjei O, Uges DR, van der Werf TS.: Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection. Antimicrob Agents Chemother. 2010 Sep;54(9):3878-83. doi: 10.1128/AAC.00099-10. Epub 2010 Jun 28.


Usman M, Ashraf M, Khokhar MI, Ashiq B, Masood MI, Afzal S, Omer O, Ali M, Qadir MI.: Comparative pharmacokinetics of levofloxacin in healthy volunteers and in patients suffering from typhoid Fever. Iran J Pharm Res. 2013 Winter;12(1):147-54.


Haeseker MB, Croes S, Neef C, Bruggeman CA, Stolk LM, Verbon A.: Vancomycin dosing in neutropenic patients. PLoS One. 2014 Nov 12;9(11):e112008. doi: 10.1371/journal.pone.0112008. eCollection 2014.


Haeseker M, Havenith T, Stolk L, Neef C, Bruggeman C, Verbon A.: Is the standard dose of amoxicillin-clavulanic acid sufficient? BMC Pharmacol Toxicol. 2014 Jul 21;15:38. doi: 10.1186/2050-6511-15-38.


Haeseker M, Stolk L, Nieman F, Hoebe C, Neef C, Bruggeman C, Verbon A.: The ciprofloxacin target AUC : MIC ratio is not reached in hospitalized patients with the recommended dosing regimens. Br J Clin Pharmacol. 2013 Jan;75(1):180-5. doi: 10.1111/j.1365-2125.2012.04337.x.


Pullen J, Stolk LM, Degraeuwe PL, van Tiel FH, Neef C, Zimmermann LJ.: Pharmacokinetics of intravenous rifampicin (rifampin) in neonates. Ther Drug Monit. 2006 Oct;28(5):654-61.


Stolk LM, Degraeuwe PL, Nieman FH, de Wolf MC, de Boer A.: Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates. Ther Drug Monit. 2002 Aug;24(4):527-31.


Hampl J, Herzig I, Vlcek J.: Pharmacokinetics of sodium humate in chickens. Vet Med (Praha). 1994;39(6):305-13.


Kostrzewski P.: Compartment simulation models and physiologic use in pharmaco- and toxicokinetics. Med Pr. 1998;49(1):83-92. [Article in Polish]



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